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However, it should be emphasized that eryptosis is definitely involved in the regulation of the immune response, directly via modifying the macrophage phenotype or indirectly by preventing proinflammatory hemolysis
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T cell granzyme-mediated GSDM activation, exogenous delivery of active GSDMs, and small molecule-induced activation of GSDMs in cancer cells have been shown to promote antitumour immunity through pyroptosis
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