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The following is a review of the preclinical and clinical studies examining the role of GLP-1R agonists on the vascular endothelium and HFpEF: Data from preclinical studies In a study on non-diabetic mice models with arterial hypertension (simulating preconditions for HFpEF), Liraglutide treatment improved blood pressure and cardiac hypertrophy in angiotensin II-induced arterial hypertension independent of glucose/insulin modulation leading to the reversal of cardiac hypertrophy

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reported significant reductions in inflammatory markers and oxidative stress among neonates with sepsis who received melatonin as adjunctive therapy, along with a decrease in mortality risk (El-Gendy et al., 2018)

We did observe a significant change in the fasted serum insulin levels with the S

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