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By the same mechanisms (potassium channel closure-mediated membrane depolarization) as the GLP- 1 receptor, the GIP receptor activation of PKA results in the secretion of insulin
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Four months later her A1C was 7.3%, and her dulaglutide dose was increased to 1.5 mg subcutaneously once weekly with a recommended reduction in her pre-meal insulin lispro dose to 40 units (~25% decrease)
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