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Cell Journal, 18 (1), 5261

Acknowledgments This work was supported by a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science (to DK) and by a Grant-in-Aid for Young Scientists from Japan Society for the Promotion of Science (to YT)

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3 Antibiotic resistance also has a significant economic impact, as resistant cases require more costly therapies and more extended hospital stays

it compounds side-effect burden without a proportional efficacy gain

Second, it lowers glucagon release when it is not needed