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WielandLSMoffetIShadeSEmadiAKnottCGormanEFet al
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Tirzepatide-induced upregulated mRNAs were primarily associated with pathways involved in metabolic regulation, signal transduction, and endocrine function, suggesting enhanced regulation of glucose homeostasis, calcium-phosphate metabolism, and anti-inflammatory processes
At the same time, patients with long-lasting disease (maximum duration 35 years) were not excluded from the study, suggesting that oral semaglutide may also be a therapeutic choice in patients with longer disease evolution
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