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Muscle pain from rapid lean mass loss and protein deficiency tends to develop more slowly, typically becoming noticeable in weeks three to six of therapy
Stricter inspections will continue in coming weeks
As an alternative approach to improve in vivo stability of the fusion molecule, we then engineered a disulphide bridge into the exendin-4 peptide moiety (Ab#2_DSB#1) as this has been shown to improve in vitro and in vivo stability of both GLP-1 and exendin-4 analogue peptides 36
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