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Citation118 Previous work in this area has demonstrated that post BCG treatment, polymorphonuclear neutrophils (PMNs) migrate to the bladder and release tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), a cytokine that specifically induces apoptosis in tumor cells

At a cellular level, IF stimulates autophagy, promoting the clearance of damaged proteins and organelles and reducing oxidative stress within the gastrointestinal tract [73]

CYPs may also catalyze demethylation to aflatoxin P (AFP 1 ) of the parent AFB 1 molecule, resulting in products less toxic than AFB 1

These data suggest that a lack of sufficient potency may contribute to minimal efficacy observed in clinical trials

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