Pharmacists should explain that such sources often operate outside regulatory oversight, increasing the risk of receiving unapproved, substandard, or counterfeit products
doi: 10.3389/fcdhc.2025.1590530 Received 09 March 2025 Accepted 18 June 2025 Published 10 July 2025 Volume 6 - 2025 Edited by Angelo Maria Patti, University of Palermo, Italy Reviewed by Anapaula Sommer Vinagre, Federal University of Rio Grande do Sul, Brazil Jun Eguchi, Okayama University, Japan Updates Copyright 2025 Hammad, Zafar, Ullah, Faisal, Iftikhar, Waheed, Muzaffar, Ahmed, Ashraf, Zahid, Akhtar and Mahmmoud Fadelallah Eljack
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Notably, GSH binding motif is not conserved among the other seleno-GPxs (GPx2, GPx3, GPx4, and GPx6) justifying their abilities to use wide variety of thiols like cysteine, protein thiols, mercaptoethanol, and dithiothreitol in addition to GSH as reducing equivalent for the catalysis [8, 17, 18]
These factors may reduce total energy, protein or micronutrient intake