Genetic association studies revealed associations of this polymorphism with maternal risk of DS birth either alone (Zampieri et al., 2012b), or in combination with MTR (combined TCN2 776CC/ MTR 2756AG genotype) (Fintelman-Rodrigues et al., 2009) or MTHFR (combined TCN2 776CG/ MTHFR 677TT genotype) (Liao et al., 2014) polymorphisms
Prog Clin Biol Res 321:383402 Ruzicka L, Bradford YM, Frazer K, Howe DG, Paddock H, Ramachandran S, Singer A, Toro S, Van Slyke CE, Eagle AE, Fashena D, Kalita P, Knight J, Mani P, Martin R, Moxon SAT, Pich C, Schaper K, Shao X, Westerfield M (2015) Zfin, the zebrafish model organism database: Updates and new directions
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