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Dumping stomach following gastrojejunostomy

Retatrutide is a triple-receptor agonist (GLP-1, GIP, and glucagon), whereas tirzepatide is dual-pathway (GLP-1 + GIP) and semaglutide is single-pathway (GLP-1 only)

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[PMID: 8583777] PubMed record related to this compound for laboratory literature review

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Post-treatment, the expression of the serotonin reuptake transporter (SERT) significantly increased, while tryptophan hydroxylase-1 (TPH-1) expression significantly decreased in colonic tissue, suggesting exendin-4 mitigates visceral hypersensitivity by upregulating SERT and downregulating TPH-1