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It is important to highlight that not all anti-diabetic drugs appear suitable for repositioning given their potential pro-tumorigenic effects.The effects of anti-diabetica drugs in thyroid cancer are summarized in Figure 1

Acute pancreatitis during GLP-1 receptor agonist treatment

However, very high doses should be avoided unless recommended by a healthcare provider

Weight loss: Both can reduce weight by slowing digestion and increasing feelings of early satiety (fullness)

NRXN1 knock-out mice models show that -neurexins are crucial for maintaining post-synaptic NMDA-receptor function, regulating synaptic transmission, and organizing the pre-synaptic terminals by coupling Ca 2+ channels on the pre-synaptic surface [50,51,52], accompanied by behavioral abnormalities that resemble the core symptoms of ASD [53]

Furthermore, we explore the evidence for perturbations in both the peripheral and central immune system, T cell activation versus T regulatory cell depletion, intracellular signalling networks including nuclear factor-B, lipid metabolism and neuroprotection