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Polonsky et al., 1984
In the U.S., about 6% of adults currently use GLP-1s, and 12% have used them in the past (2024 data) (Mozafariun 2025)
Potential side effects include: Nausea or mild stomach upset Fatigue Headache Gas or changes in bowel movements Low blood sugar (rare) If side effects are prolonged or difficult to tolerate, providers may recommend alternatives such as tirzepatide, which can have a different side effect profile.
Treatment discontinuation and reinitiation The primary outcomes were treatment discontinuation and treatment reinitiation
DOSING USED IN PHASE 3 STUDIES In the most recent studies from the TRIUMPH programme (Phase 3) , retatrutide was administered as follows: Route: Subcutaneous Frequency: Once weekly Study duration: Approximately 68 weeks Recommended Dosage (Clinical Research Escalation Model) Retatrutide is administered once weekly using a gradual dose escalation to improve tolerability
With tirzepatide, non-oral contraceptive methods should be considered for 4 weeks after initiation and dose increases due to reduced oral contraceptive efficacy
