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The evidence base is substantial: Novo Nordisk reported REDEFINE 1 met its primary endpoint with statistically significant, superior weight loss at Week 68 vs placebo

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Orforglipron significantly reduced HbA1c to 2.1% in a phase II clinical trial assessing its use in T2DM, while dulaglutide achieved 1.1% and a placebo achieved 0.43% [106]

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