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This article is part of the Topical Collection on Cardiometabolic Disease and Treatment

Approved by the FDA, it allows patients access to the same GLP-1-based science in a non-injectable format

In STZ-induced diabetic mice, proximal tubule specific knockout of phosphofurin acidic cluster sorting protein 2 (PACS-2) gene severely impaired reticulophagy of tubular cells and aggravates kidney injury

The practical result is that IGF-1 LR3 requires once-daily dosing and circulates freely in plasma longer, producing sustained receptor activation whereas native IGF-1 would require continuous infusion to maintain therapeutic levels

For instance GLP-1 alone has at least 2 isoforms, GIP has at least 4 and Glucagon at least 3

Yes, patients can take GLP-1 pills after bariatric surgery, but this is where things become more nuanced