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Since previous studies have linked the activation of NRF2 with the repression of lipogenic gene expression 64 , we reasoned that GSH depletion causes oxidation and consequent inactivation of KEAP1 (a repressor of NRF2), thus leading to increased antioxidant and decreased lipogenic gene expression

Based on Phase 2 data, retatrutide's side effect profile is consistent with the GLP-1 class: nausea, vomiting, diarrhea, and constipation, most prominent during dose escalation and typically resolving over time

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symptoms of pancreatitis - severe pain in your upper stomach spreading to your back, nausea with or without vomiting, fast heart rate