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Delayed gastric emptying (gastroparesis) is a possible mechanism, as food sitting longer in the stomach provides more opportunity for bacterial activity downstream in the digestive process

Finding access to them was the first hurdle

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Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes

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However, due to the complexity of the composition of the microbiome and its effect on the organism, future research needs to gain a deeper understanding of the esophageal and intestinal microbiome and their metabolites in GERD through basic research to understand how the microbiome and their metabolites influence the occurrence of GERD, and also in the pathogenesis of GERD, abnormalities in digestive tract dynamics are gradually being emphasized by researchers