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7 According to a study done by Bernardo Yusta from the University of Toronto in Toronto, Canada and colleagues, treatment of diabetic rats with exendin-4 can significantly reduce biochemical markers of islet endoplasmic reticulum (ER) in beta cells

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2015 Sep 9;2(4):144-149

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In contrast, metformin did not cause significant changes in any of the metabolic parameters under analysis (Fig

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