This surge reflects recognition that GLP-1 therapy addresses the underlying biology of appetite regulation rather than relying solely on behavioral modification
Most patients experience no adverse effects, and when present, theyre typically mild and transient including temporary digestive changes as the gut adjusts, minor nausea (usually resolving within days), or altered bowel patterns during initial therapy
A 2026 UK review of the May 2026 UCSF Annals of Neurology study showing "normal" but lower active B12 is linked to slower thinking and more white-matter brain injury, NICE NG239, the homocysteineDNA-methylation mechanism that suppresses hippocampal neurotrophins, the VITACOG brain-atrophy trial, pernicious anaemia, metformin and PPI depletion and why replacing the B12 comes first, not a peptide Read the full review Metabolic Neuropsychiatry & Cognitive Health 20 May 2026 Dihexa & GLP-1 Drugs (Ozempic, Wegovy, Mounjaro) and the Brain: The 2026 UK Review Do GLP-1 drugs like Ozempic, Wegovy and Mounjaro protect the brain or cause brain fog
Inhibiting NNMT has been proposed as a therapeutic strategy for metabolic disease
Sourris KC, Ding Y, Maxwell SS, Al-Sharea A, Kantharidis P, Mohan M, et al
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