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BW loss was significantly larger in the semaglutide group than in the DPP-4 inhibitor group ( 2.3 1.8 vs

DeGironemo , a double board-certified physician recognized for excellence in aesthetic and regenerative medicine

It also notes the reverse pattern, where someone reports minimal symptoms in the first 72 hours and then experiences cumulative gastrointestinal effects around day four or five

"GI AEs typically occur during initiation and uptitration, appearing as transient, mild-to-moderate symptoms." Laura Schalliol, PharmD, BCACP, BCGP, Professor of Pharmacy Practice In fact, 94% of adverse events reported in major clinical trials were mild or moderate in severity

(PubMed) Shahmiri SS, Eghbali F, Ismaeil A, et al

While mildly disruptive to daily routines, these side effects are considered normal while on Zepbound and are generally tolerable to most patients