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Typically, healthcare providers recommend checking kidney function every 3 to 6 months, but this may vary based on individual health needs

Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)

Traish AM, Park K, Dhir V, Kim NN, Moreland RB, Goldstein I

Step 2: Prepare the Injection Device If using a prefilled pen, follow the manufacturers instructions to prepare the dose

The most common side effect is stomach discomfort (typically in the form of bloating), especially during a loading phase, where people take 20-25 grams daily

Caution: For external use only