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It may be that the modulation of glutamate catabolism serves to maintain the intracellular glutamate/2-oxoglutarate ratios which is known to co-ordinate a number of cellular activities such as growth rate modulation [40]

ROS are highly reactive radical and non-radical forms of oxygen comprising superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and highly reactive hydroxyl (OH) groups that are produced during oxygen metabolism during photosynthesis, oxidative phosphorylation, and peroxisomal activity 10,11

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FYCO1 regulates cardiomyocyte autophagy and prevents heart failure due to pressure overload in vivo

Suitable for cell-based assays and molecular pathway analysis