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Abstract:Chronic hyperglycemia in diabetics causes microvascular damage through four mechanisms of biochemical changes, including activated protein kinase C (PKC) pathway, activated hexosamine pathway, increased polyol pathway, and increased advanced glycation end-products (AGEs), all of which will increase Reactive Oxygen Species (ROS) levels

As with all longevity compounds, realistic expectations matter this may support cellular energy and repair pathways over time rather than producing an immediate, noticeable effect

Based on the current level of evidence, other authors have also suggested the use of oral or topical glutathione as an adjunctive therapy for facial melanosis

Erratum in: J Cell Sci

Statements Author contributions LC contributed in collecting bibliography, in writing the manuscript, and in conceiving and creating the figures

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