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And to do that, regardless of where the injury is, they'll do that in one particular site

10.1002/iub.1262 IUBMB Life 153 PittsM

Although certain disease-causing VCP mutants (R155H, R159G, and R191Q) are resistant to the methylation-promoting effects of ASPL, the physiologic consequences of this posttranslational modification (which reduces VCP activity) and how it relates to disease remain unclear ( 55 )

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Inconsistency during this phase significantly diminishes outcomes

WT samples for each peptide-spectra match by dividing each TMT reporter ion intensity by the average intensity for the channels corresponding to WT control (3 per TMT sample)