semaglutide news oct 26 2025 Tirzepatide outperformed weight-loss drug results in real world patients, study shows GLP-1 trends 2025: real-world data,

No anhedonia or fatigue : A documented side effect from these meds is anhedonia, the blunting of pleasure/joy, and some users report fatigue

Then, food-derived glutathione induces mild oxidative stress upon entering the cell, which could elevate PGC-1

Lipids: triglycerides, non-HDL and ApoB after GLP-1s A lipid panel is worth repeating after 3-6 months on GLP-1 therapy because triglycerides, non-HDL cholesterol and sometimes ApoB improve with weight loss and better insulin sensitivity

Five of these patients had a biopsy at another institution (including three excisional biopsies), and five were referred to INEN with a melanoma diagnosis

Seven additional Phase 3 readouts expected throughout 2026

These effects do not occur all at once