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This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

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Step 1: GHK-Cu subcutaneous injection Before or at the session, GHK-Cu is administered via subcutaneous injection

Further analysis via western blot and DNA fragmentation ELISA analysis showed that TNF addition increased PARP cleavage (a marker of apoptosis

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Pro-apoptotic signaling of JNK1 is mediated by the upstream MAP3K apoptosis signal-regulating kinase (ASK1) cascade (147)