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If the regained weight is disproportionately fat, individuals may ultimately be worse off than before in their fat-to-lean mass ratio, which may have adverse consequences for their health. The researchers say there are several limitations to their study

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Rohm, M

[1] [2] This effect may diminish over time with continued use

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Additional analyses were conducted with a modified intention-to-treat definition for drug use so that patients were censored from follow-up on the date of switch to, or add on of, the other study drug (ie, follow-up among patients treated with DPP4 inhibitors was censored on the date of a GLP1 receptor agonist prescription, and vice versa)