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Research Background FOXO4-DRI has been studied in preclinical senescence research for its proposed ability to selectively induce apoptosis in senescent cells by disrupting FOXO4-p53 binding

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3 Mechanisms of ferroptosis in cancer cells Ferroptosis is tightly associated with iron-dependent lipid peroxidation and involves multiple cellular events, including iron metabolism, lipid peroxidation and antioxidant defense, which has been proven to contribute to modulating initiation and progression of cancer (Figure 1)

Beyond the observed increase in female lifespan, we show that pharmacologic blockade of IGF-1R signaling preserves, to various degrees, many aspects of healthspan, including neuromuscular function and endurance, and attenuates the age-related increase in diastolic dysfunction, systemic inflammation, and neoplasias in females

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