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Glutathione is a small protein that is naturally produced in plants and animals

The stress of midlife (and menopause!) is a factor as well

Splunter MV, Perdijk O, Fick-Brinkhof H, Floris-Vollenbroek EG, Meijer B, Brugman S, et al

In papillary thyroid carcinoma (PTC), the most common form of thyroid cancer, IGFBP-5 expression is targeted by miR-204-5p [69], in contrast with the alternate precursor product, miR-204-3p, which was noted earlier as targeting IGFBP-2 in glioma [43]

This being said, one potential remedy might involve use of antioxidants, which are mostly taken as supplements, together with radiation therapy and/or chemotherapy that causes cellular oxidative damage (11, 12)

doi:10.1016/j.ypmed.2014.09.018 Stuebe A