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Expert Opin Biol Ther 18:343351 Holscher C (2014) Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases

140,147,153,155,159 However, statins are known to exhibit high interindividual variability in terms of pharmacokinetics, and GLP-1 RA administration did not affect the lipid-lowering effect of statins in clinical studies, indicating minimal clinical significance

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Signaling through GLP-1R is not necessary for nutrient-mediated AgRP neuron inhibition