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Starting with a low dose and gradually reaching the maintenance level is essential for safe and effective weight management

10.1002/cne.24905 J

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Phentermine is FDA-approved for short-term use, typically up to 12 weeks, and GLP-1 medications are designed for long-term, ongoing weight management under provider supervision

Notably, the STEP (Semaglutide Treatment Effect in People with obesity) trials, which specifically examined body composition, demonstrated substantial weight loss compared with placebo (NCT03548935) [53], and reductions in fat mass and visceral adipose tissue were accompanied by decreases in lean mass, although the proportion of lean mass relative to total body mass increased (NCT04074161) [54]

A specific role for IGF-1 receptor (IGF-1R) signaling in the mediation of mammalian longevity was first established in IGF-1R haploinsufficient mice, which lived 33% longer than controls, but unlike other models of reduced somatotropic signaling, this effect was female specific 6