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First, they should be biologically interpretable: a metabolite panel should map to a pathway such as FAO bottleneck, glycolytic rerouting, mitochondrial stress, BCAA catabolic defect, NAD + depletion, ketone adaptation, or ferroptosis

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These include avoiding alcohol, eating a balanced diet, maintaining a healthy weight, and staying physically active as advised

These equivocal results might be explained by the sample size, the ethnic background, and the lifestyle of studied subjects