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Overview: Two Distinct Pathways for GH Regulation with Peptides Growth hormone secretion from pituitary somatotrophs is regulated by multiple neurohormonal pathways that evolved to provide fine-tuned control over this critical metabolic hormone

10.1016/j.neuron.2021.03.022 Neuron 140 RaoY.DuS.YangB.WangY.LiY.LiR.et al (2021)

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If your GLP-1 receptors are genetically suboptimal but your GIP receptors function normally, tirzepatide can deliver results through the alternative pathway

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Heres what you need to do: They recommend five key supplements that may help maintain muscle and metabolic health while on GLP-1s: Your gut microbiome plays a major role in your metabolic function