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By 1926, Minot and Murphy reported clinical and hematological improvement in 45 patients with pernicious anemia treated with a dietary regimen that incorporated large quantities of liver (Minot and Murphy 1926
The AOD9604 knockout-mouse study supports an association between chronic AOD9604 responses and beta-3-receptor expression or availability, but it does not establish AOD9604 as a classical direct beta-3-receptor agonist
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Originally developed as an anti-obesity drug candidate in the late 1990s, it has since found research applications in both metabolic studies and cartilage repair investigations
Cell Host Microbe 26 (2), 265-272.e4
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