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In catabolic circumstances, the levels of IGF-1 decrease while its binding proteins increase, leading to a lower local IGF-1 activity and contributing to the decreased insulin sensitivity seen in catabolism

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MT1's structural linearity and MC1R selectivity distinguish it from MT2, whose cyclic architecture and multi-receptor engagement make it a different research tool for melanocortin system studies

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Mahmood S, Mandal U, Chatterjee B, Taher M