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Effects of a thiazide diuretic (hydroflumethiazide) and a loop diuretic (bumetanide) on the endocrine pancreas: studies in vitro

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GSTO1 inhibition is cytotoxic to cancer cells We evaluated the expression of GSTO1 in various tumour types using publicly available gene expression data sets from the Oncomine database

In addition, proteins of the suppressor cytokine signaling (SOCS) family are synthesized, acting as a negative feedback mechanism

These effects depend on integrin alpha-1 and beta-1 pathway activation

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