Mendelian randomization evidence indicates that elevated KYN levels have a causal relationship with increased risk of depression, with each standard deviation increase in KYN corresponding to ~ 1.4-fold higher odds of developing depression [50]
Endocrinology Targeting the central melanocortin system for the treatment of metabolic disorders 2023 DOI: 10.1038/s41574-023-00855-y PMID: 37365323 Sweeney P, Gimenez LE, Hernandez CC, et al
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Given the documented effects of GLP-1 and GLP-2 on rodent liver regeneration and their routine therapeutic targeting for other indications, we sought to explore perioperative dynamics of GLP-1 and GLP-2 in patients undergoing hepatic resections
Lenzi A, Gandini L, Picardo M, Tramer F, Sandri G, Panfili E
This distinction matters because abnormal glucose, liver enzymes, kidney markers, lipids, or nutritional markers may predate semaglutide use
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