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Rapid weight loss and muscle wasting
This effect is temporary and usually mild
The duration of fatigue associated with GLP-1 medications varies considerably between individuals, but there are recognisable patterns that can help set realistic expectations
Mindfulness, meditation, deep breathing exercises, and adequate sleep all help regulate the neurological systems involved in sensory processing
Patients with a history of pancreatitis, symptomatic gallbladder disease, or severe gastroparesis warrant careful discussion as well, since GLP-1s slow gastric emptying and can exacerbate these conditions
Some patients will discontinue the medication prematurely if these symptoms are too severe or persist for too long, potentially reducing therapeutic gains
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