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Key points Hypothyroidism slows metabolism and leads to weight gain, fatigue, and fluid retention

doi:10.1056/NEJMoa2032183 Cava E, Yeat NC, Mittendorfer B

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Starting with high doses (1,000 mcg to 2,000 mcg) weekly or biweekly is common

[25] Murine cells overexpressing the NADase CD38 consumed less oxygen, had higher lactate levels, and had abnormal mitochondria, including traits like missing or enlarged cristae, which lends more proof of NAD+s role in promoting mitochondrial and metabolic health