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Both contribute to the normal protection of cells from oxidative stress and the normal function of the immune system

Kwizer et al [7] have examined the effects of hepatotoxic drugs such as paracetamol, cocaine, dextropropoxyphene and hycanthone on glutathione content of isolated rat hepatocytes and reported that addition of a hepatotoxic drug caused a rapid fall in glutathione content

HGF was first reported structurally similar to plasminogen in early 1980s, which was further characterized by a new substance responsible for liver regeneration in the serum of partially hepatectomized rats [3]

24 Consequently, the findings of the current research revealed that roflumilast was successful in safeguarding Wistar rat livers from methotrexate-induced acute hepatotoxicity

Journal of Drugs in Dermatology, March 2015, pages 271-280 6