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Strikingly, treatment with a lower dose of methazolamide (daily dose of 200 mg) also resulted in notable improvements in AMS symptoms, particularly headache, irritability, feeling unwell and loss of concentration

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Replacement of Glu170 in E170A/K resulted in a 5060% decrease of the k cat app values for GSH but had a rather minor effect on the k cat app (HEDS) values (Fig

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Further reactions catalyzed by CYP17A1 lead to 17-hydroxypregnenolone and dehydroepiandrosterone