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Clin Chim Acta 2005;360:173-7
Therefore, there is an unmet need for new and effective treatments for obesity and type 2 diabetes
Using a model of streptozotocin diabetes in rats in vivo and HT-22 cells in vitro, it was shown that GLP-1RA liraglutide improves the cognitive abilities of rats with diabetes mellitus and can have a protective effect by reducing oxidative stress, suppressing the expression of -secretase (BACE1) and -secretase, as well as reducing the deposition of -amyloid by triggering signaling mechanisms associated with NF-kB and ERK1/2 [30]
These comorbid conditions should warrant additional baseline/ongoing evaluation of mental health issues during this long-term therapy
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