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(2023) 15:e51352

Elevated NAD+ levels activate sirtuins, particularly SIRT1, which are NAD+-dependent deacetylases that regulate numerous metabolic processes including fat oxidation, glucose metabolism, mitochondrial biogenesis, and cellular stress responses

This piece in 1993 also provided new insights into the biology of exendin, namely that exendin-4 was a full agonist of the human GLP-1 receptor, which Mojsov argues was crucial to convincing Amylin to develop exendin as a drug for diabetes (see below)

A standalone comorbid indication is defensible on mechanistic grounds and would allow a tighter label with stronger effect size claims

The amount of weight loss in the bimagrumab 30 mg/kg/semaglutide 2.4 mg group is similar to that seen with tirzepatide (Zepbound, Eli Lilly) and cagrilintide 2.4 mg/semaglutide 2.4 mg (CagriSema, Novo Nordisk), but the percentage of weight loss from fat mass was much higher than for tirzepatide or semaglutide, Aronne said

These metabolic improvements may indirectly support reproductive health by reducing inflammation, improving insulin sensitivity, and restoring hormone production