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In the STEP 1 trial, semaglutide 2.4 mg produced approximately 15% weight loss at 68 weeks, while the SURMOUNT-1 trial showed tirzepatide achieved 15-21% weight loss at 72 weeks when combined with lifestyle modifications

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(1) J Ishida, M Saitoh, N Ebner, J Springer, et al (2020) Growth hormone secretagogues: history, mechanism of action, and clinical development JCSM Communications, Volume 3, Issue 1, January/June 2020, Pages 25-37