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Age: absorption naturally slows as we get older, so timing can shift over the years
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It is well-tolerated in animal and early clinical studies, even at multi-milligram doses [12]
Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation
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No deficiency, no predictable energy benefit NIH and Mayo Clinic note that B12 supplementation has not been shown to improve energy, endurance, or athletic performance in people whose B12 status is already sufficient
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