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Tirzepatide is a once-weekly injectable, dual glucagon-like peptide 1 (GLP-1) receptor and glucose-dependent insulinotropic polypeptide (GIP) receptor agonist
However, achieving clinical success will require overcoming challenges related to the selective targeting of these cells without affecting normal immune function
The SURMOUNT-5 trial, published in The New England Journal of Medicine in May 2025, is the first large randomized study to compare tirzepatide and semaglutide directly in adults with obesity
doi: 10.1038/s41586-022-05473-8 15 BovijnJJacksonLCensinJChenCYLaiskTLaberSet al
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Instead, theyre made from herbal blends or vitamins with no clinical evidence backing their effectiveness for weight loss or metabolic health
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