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Sleep disturbances Some people report insomnia on semaglutide , particularly at higher doses

Adverse events occurred in 83.8%, QW/QW, and 84.6%, QW/Q2W, of patients with cendakimab and 73.4% with placebo through week 48

And most people on GLP-1s are also obese or overweight, increasing the likelihood of reflux

KawaguchiYShimauchiRNishiboriNKawashimaKOshitaniSFujiyaAet al

And the question of whether people can maintain weight loss after going off GLP-1 medications is an ongoing area of study: The science is far from settled

Using 2025 adult population statistics, Leger Healthcare extrapolated that would equal about three million Canadian adults