At 48 weeks, the liver fat reductions were even more pronounced, with approximately 90% of individuals receiving maximum dose levels achieving normalization of liver fat [25]
Switch to a different GLP-1 agonist like semaglutide , which some people tolerate better
Does tirzepatide work faster than semaglutide
Injection into sensitive or low-fat tissue: Areas such as the abdomen, inner thigh, or other sites with minimal subcutaneous fat have less tissue cushioning and a higher density of sensory nerve endings, making pH-related discomfort more noticeable
If your calculated dose requires a volume larger than your syringe can hold, you can split it into two injections given at the same time in different sites
This bridging approach can help maintain appetite control while the tirzepatide dose decreases