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Use: As an adjunct to a reduced-caloried diet and increased physical activity for chronic weight management in pediatric patients with a body weight above 60 kg and an initial BMI of 30 kg/m2 or greater

Their hormonal systems, bone density, and metabolic pathways are in flux

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Standardized to 6-paradol, the primary active compound studied for its role in supporting thermogenesis and metabolic rate.

Identification of the peptide and receptors, however, does not by itself substantiate a functional relevance, but evidence for a physiological role of these receptor populations emerged 13 years later and will be discussed here

Semaglutide solves both problems with three small changes to the native GLP-1(7-37) sequence