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However, it causes substantially more injection site reactions

For these two conditions, the gut disruptions lead to problems with the gut-brain-immune axis, which lead to inflammation both inside and outside the brain

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Collectively, these factors provide a biologically and methodologically plausible basis for divergent findings across outcomes

Whilst improved insulin sensitivity generally has favourable hormonal effects, rapid weight loss can temporarily disrupt hormone levels, including sex hormones and cortisol

Donaldson K, J.C., Hunt HJ