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GLP-1R + ChAT + neurons were also observed in the other two autonomic nuclei, the ICN and CAA

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It should be noted that it is extremely difficult to define the optimal gut microbiota, since individuals have different gut microbiota composition, and even in the same host, the gut microbiota have complex variations and evolutions during the whole life cycle due to various diets, environments, genes expression, and so on [234,235,236,237,238,239]